Molecular Biology
Scientific Leadership
Shahid S. Siddiqui, Ph.D.
Chair & Professor of Foundational Biology
Niazee College of Osteopathic Medicine (NCOM), Schaumburg, Illinois
Founder & CEO, McGenome LLC
50+ Years of Science
S. S. Siddiqui
Translating decades of motor protein genetics into life-saving precision diagnostics and therapeutics.
McGenome LLC was founded on a simple premise: complex inflammatory and rare genetic conditions require race-calibrated, multi-omic perspectives to resolve therapeutic and diagnostic gaps.
Dr. Siddiqui holds the inaugural appointment of Chair and Professor of Foundational Biology at the Niazee College of Osteopathic Medicine (NCOM) in Schaumburg, Illinois, effective July 1, 2026, where he is establishing a dedicated C. elegans and human cell research laboratory. NCOM is a proposed osteopathic medical college in Candidate Status with the Commission on Osteopathic College Accreditation (COCA), with an anticipated opening in 2027. The laboratory at NCOM will serve as the primary experimental facility for validation of McGenome's ELEGANS-INTERACTOME and other AI/ML platforms.
The scientific foundation spans invertebrate kinesin motor characterization, alpha-tubulin structural biology, G-protein signaling pathways, and consanguineous population genetics in Middle Eastern cohorts. This comprehensive body of work uniquely positioned McGenome for the development of four patent-pending AI/ML precision medicine platforms — ELEGANS-INTERACTOME for human pathogen-host interaction discovery, SarcoActivity™ for sarcoidosis health equity, KIF7-CilioPanel™ for pediatric ciliopathy genomics, and the nmMLCK Platform for ARDS and acute lung injury.
Four Patent-Pending Programs
- ELEGANS-INTERACTOMEGraph Neural Network (GNN) platform predicting direct pathogen-host protein-protein interactions from sequence alone.
- SarcoActivity™Race-calibrated AI/ML diagnostics for sarcoidosis health equity, correcting rs1799752 polymorphism and ACE-i pharmacologic suppression.
- KIF7-CilioPanel™An 11-gene tiered NGS diagnostic platform utilizing functional Hedgehog assays for rare pediatric ciliopathies.
- nmMLCK TherapeuticsIsoform-specific silencing of non-muscle myosin light chain kinase in ARDS to prevent paracellular microvascular leak.
Core Credentials
Scientific and translational foundation
PhD
Molecular Biology and Genetics
MS
Biochemistry
USPTO
Registered Micro Entity · 4 Patent-Pending Platforms (ELEGANS-INTERACTOME, SarcoActivity™, KIF7-CilioPanel™, nmMLCK)
NCOM
Chair and Professor of Foundational Biology, Schaumburg, Illinois
NIH STTR
Phase I Applicant (NHLBI, NIMHD, NICHD mechanisms)
SAM Registration
Active, Notarized Unique Entity ID (UEI) registered for government awards
Governance
Scientific Leadership & Advisory Boards
Combining clinical insight, computational rigor, and regulatory strategy to translate multi-omic research.
CEO & Leadership
Driving the strategic vision for AI/ML-enabled biomarker science.
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Dr. Shahid S. Siddiqui, Ph.D.
Founder and CEO, McGenome LLC
Chair and Professor of Foundational Biology, NCOM, Schaumburg, Illinois
Cross-Domain Leadership
Drug & Device DevelopmentRegulatory AffairsMolecular Biology
Molecular biologist and developmental geneticist with over 40 years of experience. Founded McGenome in 2004. Has developed siRNA-based reagents, obtained international patents, and contributed to drug clinical trials in oncology and cardiovascular diseases.
MD Physician Advisory Panel
Ensuring clinical relevance and translational validity for all biomarker hypotheses.
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Dr. Janie Myers, DO, DFACOS, FACS
Distinguished Fellowship Trained Surgeon
Rare Diseases & Systemic Conditions
Advanced Surgical TechniquesHealthcare Leadership
Leads Myers Surgical Associates honing skills in both advanced surgical techniques and business management. At the National Board of Osteopathic Medical Examiners, her role melds healthcare leadership with a steadfast commitment to regulatory compliance and utilization management.
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Prof. Dr. Timothy Andersson, Ph.D.
Clinical Research Expert
Dermatological & Systemic Autoimmune
Stem Cell ResearchClinical StudiesMedical Therapeutics
Has conducted phase three clinical studies demonstrating that plant stem cells in a proprietary vehicle were safe, tolerable, and significantly more beneficial in contributing superior clinical efficacy to treat various dermatological conditions and reverse aging.
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Douglas Yau, Ph.D, MBA, CMD
Executive Director Oncology Medical Affairs
Paediatric & Adult Oncology
Oncology Medical StrategyImmuno-oncologyAngel Investing
Inspirational Medical Affairs Leader with 15 years of experience in Biological Sciences and over 10 years specifically in Hematology and Oncology. Provides strategic leadership for national Oncology Solid Tumor Teams, supporting multiple successful Immuno-oncology drug launches.
Computational Science & Regulatory Team
Executing the multi-omic analytical pipelines and navigating FDA qualification pathways.
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Dr. Robert Holmgren, PhD
Director of Biological Programs
Rare Paediatric Cancer
Human GeneticsRare DiseaseHedgehog Signaling
Distinguished researcher with 40 years studying Hedgehog signal transduction, which plays a central role in animal development and human disease. His contributions include identification of new pathway components and development of compounds to block Hedgehog signaling in cancer.
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Dr. Syed Shahabuddin, Ph.D.
Drug Development Strategist
Sarcoidosis & Fibrotic Diseases
Small MoleculesGene TherapyCell Therapies
Drug development strategist with over 25 years of experience advancing therapeutics from discovery through late-stage clinical development. Founder of SS BioPharma Consulting, advising on cross-functional program execution.
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Dr. Jaseem Anwer, PhD
Scientific Director
Brain-Gut Axis
ToxicologyPharmacokineticsSafety Pharmacology
Leads analytical, bioanalytical, and safety pharmacology studies across various models. Over 20 years of experience in designing pre-clinical GLP and non-GLP studies.
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Dr. Haris Jamil, PhD
Pharmaceutical Development Leader
Biomarker Qualification
Analytical DevelopmentBiologics
Accomplished leader with three decades of experience guiding drug development across small molecules, peptides, and biologics. Contributed to major regulatory milestones including filing several INDs at Bristol-Myers Squibb.
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Dr. Shahab U. Khan, Ph.D.
Chief Scientific Officer
Grant Strategy & NIH Proposals
Clinical DevelopmentMedical Writing
Possesses deep proficiency in the full life cycle of clinical development. Experienced leader with a proven history of high-quality medical writing, including complex clinical protocols and successful grant proposals.
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Dr. Zeba K. Siddiqui, Ph.D.
Chief Financial Officer
Systemic Inflammation
Molecular ImmunologyStrategic Funding
Highly experienced molecular immunologist with research in pulmonary endothelial function and cell death pathway signaling. Has published in top-ranked peer-reviewed journals.
Global Network
International Scientific Affiliations
Advisory and educational leadership bridging oncology and precision medicine networks globally.
Pharmatica — Senior Scientific Council
Vanguard Science Education Platform · South Africa / United Kingdom
OncologyPrecision MedicinePharmatica Forum
Pharmatica is an international science education platform connecting clinicians, researchers, and industry professionals across Africa, Europe, and beyond. Dr. Siddiqui contributes as a Senior Scientific Council member, providing educational content on oncology advances, molecular diagnostics, and the application of AI/ML to drug development and disease monitoring. Webcasts and scientific resources are accessible through the Pharmatica platform.
Official Website: pharmatica.io
Research Space
Core Scientific Disciplines
Our research is cross-disciplinary, bringing computational and wet lab practices together.
Toxicology
Oncology
Regulatory Affairs
Biostatistics
Immunology
Archives
Selected Publications
Peer-reviewed evidence establishing the scientific basis of our platforms.
Human Genomics
2026
Alafghani et al. (Human Genomics, 2026) - KIF7 c.2992C>T (p.Gln998Ter) novel stop-gain variant in Saudi consanguineous Joubert syndrome and related disorder (JSRD) families. Scientific foundation for the KIF7-CilioPanel(tm) platform.
Genomics
2016
Al-Allaf et al. — Recurrent LDLR frameshift in homozygous Saudi Arab children with familial hypercholesterolemia. Autosomal recessive founder allele genetics.
PNAS
2003
Yau et al. — Worm Gα12 activates the Rho guanine nucleotide exchange factor CGEF-1 to regulate cytoskeletal dynamics and cell migration.
J Cell Science
1999
Siddiqui — MEC-12 alpha-tubulin acetylation in C. elegans mechanosensory neurons. Axonemal scaffold biology.
J Mol Biol
1995
Tabish et al. — OSM-3 kinesin isoform selectively maintains sensory ciliary compartment identity in C. elegans. Foundational precedent for KIF7 ciliary tip biology.
DNA Research
2000
Khan et al. — KLP-11 / KAP-1 kinesin heterodimer in C. elegans sensory neurons. Ciliary transport mechanism.