Shahid S. Siddiqui, MS, PhD
Founder & CEO, McGenome LLC
Chair and Professor of Foundational Biology
Niazee College of Osteopathic Medicine (NCOM) · Schaumburg, IL
30+ Years of Science
Translating decades of motor protein genetics into life-saving precision diagnostics and therapeutics.
McGenome LLC was founded on a simple premise: complex inflammatory and rare genetic conditions require race-calibrated, multi-omic perspectives to resolve therapeutic and diagnostic gaps.
The scientific foundation spans invertebrate kinesin motor characterization, alpha-tubulin structural biology, G-protein signaling pathways, and consanguineous population genetics in Middle Eastern cohorts. This comprehensive body of work uniquely positioned McGenome to solve ciliary signaling mechanics in Joubert syndrome, correct ACE monitoring failures in African American sarcoidosis, and silence endothelial vascular leak pathways in ARDS.
Three Patent-Pending Programs
- SarcoActivity™Race-calibrated AI/ML diagnostics for sarcoidosis health equity, correcting rs1799752 polymorphism and ACE-i pharmacologic suppression.
- KIF7-CilioPanel™An 11-gene tiered NGS diagnostic platform utilizing functional Hedgehog assays for rare pediatric ciliopathies.
- nmMLCK TherapeuticsIsoform-specific silencing of non-muscle myosin light chain kinase in ARDS to prevent paracellular microvascular leak.
Core Credentials
Scientific and translational foundation
PhD
Molecular Biology and Genetics
MS
Biochemistry
USPTO
3 Patent-Pending Platforms (SarcoActivity™, KIF7-CilioPanel™, nmMLCK)
NCOM
Chair and Professor of Foundational Biology, Schaumburg, Illinois
NIH STTR
Phase I Applicant (NHLBI, NIMHD, NICHD mechanisms)
SAM Registration
Active, Notarized Unique Entity ID (UEI) registered for government awards
Scientific Leadership & Advisory Boards
Combining clinical insight, computational rigor, and regulatory strategy to translate multi-omic research.
CEO & Leadership
Driving the strategic vision for AI/ML-enabled biomarker science.
Dr. Shahid S. Siddiqui, Ph.D.
Founder and CEO, McGenome LLC
Chair and Professor of Foundational Biology, NCOM, Schaumburg, Illinois
Molecular biologist and developmental geneticist with over 40 years of experience. Founded McGenome in 2004. Has developed siRNA-based reagents, obtained international patents, and contributed to drug clinical trials in oncology and cardiovascular diseases.
MD Physician Advisory Panel
Ensuring clinical relevance and translational validity for all biomarker hypotheses.
Dr. Janie Myers, DO, DFACOS, FACS
Distinguished Fellowship Trained Surgeon
Leads Myers Surgical Associates honing skills in both advanced surgical techniques and business management. At the National Board of Osteopathic Medical Examiners, her role melds healthcare leadership with a steadfast commitment to regulatory compliance and utilization management.
Prof. Dr. Timothy Andersson, Ph.D.
Clinical Research Expert
Has conducted phase three clinical studies demonstrating that plant stem cells in a proprietary vehicle were safe, tolerable, and significantly more beneficial in contributing superior clinical efficacy to treat various dermatological conditions and reverse aging.
Douglas Yau, Ph.D, MBA, CMD
Executive Director Oncology Medical Affairs
Inspirational Medical Affairs Leader with 15 years of experience in Biological Sciences and over 10 years specifically in Hematology and Oncology. Provides strategic leadership for national Oncology Solid Tumor Teams, supporting multiple successful Immuno-oncology drug launches.
Computational Science & Regulatory Team
Executing the multi-omic analytical pipelines and navigating FDA qualification pathways.
Dr. Robert Holmgren, PhD
Director of Biological Programs
Distinguished researcher with 40 years studying Hedgehog signal transduction, which plays a central role in animal development and human disease. His contributions include identification of new pathway components and development of compounds to block Hedgehog signaling in cancer.
Dr. Syed Shahabuddin, Ph.D.
Drug Development Strategist
Drug development strategist with over 25 years of experience advancing therapeutics from discovery through late-stage clinical development. Founder of SS BioPharma Consulting, advising on cross-functional program execution.
Dr. Jaseem Anwer, PhD
Scientific Director
Leads analytical, bioanalytical, and safety pharmacology studies across various models. Over 20 years of experience in designing pre-clinical GLP and non-GLP studies.
Dr. Haris Jamil, PhD
Pharmaceutical Development Leader
Accomplished leader with three decades of experience guiding drug development across small molecules, peptides, and biologics. Contributed to major regulatory milestones including filing several INDs at Bristol-Myers Squibb.
Dr. Shahab U. Khan, Ph.D.
Chief Scientific Officer
Possesses deep proficiency in the full life cycle of clinical development. Experienced leader with a proven history of high-quality medical writing, including complex clinical protocols and successful grant proposals.
Dr. Zeba K. Siddiqui, Ph.D.
Chief Financial Officer
Highly experienced molecular immunologist with research in pulmonary endothelial function and cell death pathway signaling. Has published in top-ranked peer-reviewed journals.
International Scientific Affiliations
Advisory and educational leadership bridging oncology and precision medicine networks globally.
Pharmatica — Scientific Council Member
Vanguard Science Education Platform · South Africa / United Kingdom
Pharmatica is an international science education platform connecting clinicians, researchers, and industry professionals across Africa, Europe, and beyond. Dr. Siddiqui contributes as a founding Scientific Council member, providing educational content on oncology advances, molecular diagnostics, and the application of AI/ML to drug development and disease monitoring. Webcasts are available through the Pharmatica forum.
Webcasts launching 2026 — link will be updated.
Core Scientific Disciplines
Our research is cross-disciplinary, bringing computational and wet lab practices together.
Selected Publications
Peer-reviewed evidence establishing the scientific basis of our platforms.
Alafghani et al. — KIF7 c.2992C>T, CEP104 c.489+1G>A, TMEM237 c.869+1G>A in Saudi consanguineous JSRD families. Index paper for KIF7-CilioPanel™.
Al-Allaf et al. — Recurrent LDLR frameshift in homozygous Saudi Arab children with familial hypercholesterolemia. Autosomal recessive founder allele genetics.
Yau et al. — Worm Gα12 activates the Rho guanine nucleotide exchange factor CGEF-1 to regulate cytoskeletal dynamics and cell migration.
Siddiqui — MEC-12 alpha-tubulin acetylation in C. elegans mechanosensory neurons. Axonemal scaffold biology.
Tabish et al. — OSM-3 kinesin isoform selectively maintains sensory ciliary compartment identity in C. elegans. Foundational precedent for KIF7 ciliary tip biology.
Khan et al. — KLP-11 / KAP-1 kinesin heterodimer in C. elegans sensory neurons. Ciliary transport mechanism.
