Scientific Leadership

Shahid S. Siddiqui, MS, PhD

Founder & CEO, McGenome LLC

Chair and Professor of Foundational Biology
Niazee College of Osteopathic Medicine (NCOM) · Schaumburg, IL

Shahid S. Siddiqui, MS, PhD

30+ Years of Science

S. S. Siddiqui

Translating decades of motor protein genetics into life-saving precision diagnostics and therapeutics.

McGenome LLC was founded on a simple premise: complex inflammatory and rare genetic conditions require race-calibrated, multi-omic perspectives to resolve therapeutic and diagnostic gaps.

The scientific foundation spans invertebrate kinesin motor characterization, alpha-tubulin structural biology, G-protein signaling pathways, and consanguineous population genetics in Middle Eastern cohorts. This comprehensive body of work uniquely positioned McGenome to solve ciliary signaling mechanics in Joubert syndrome, correct ACE monitoring failures in African American sarcoidosis, and silence endothelial vascular leak pathways in ARDS.

Three Patent-Pending Programs

  • SarcoActivity™Race-calibrated AI/ML diagnostics for sarcoidosis health equity, correcting rs1799752 polymorphism and ACE-i pharmacologic suppression.
  • KIF7-CilioPanel™An 11-gene tiered NGS diagnostic platform utilizing functional Hedgehog assays for rare pediatric ciliopathies.
  • nmMLCK TherapeuticsIsoform-specific silencing of non-muscle myosin light chain kinase in ARDS to prevent paracellular microvascular leak.

Core Credentials

Scientific and translational foundation

PhD

Molecular Biology and Genetics

MS

Biochemistry

USPTO

3 Patent-Pending Platforms (SarcoActivity™, KIF7-CilioPanel™, nmMLCK)

NCOM

Chair and Professor of Foundational Biology, Schaumburg, Illinois

NIH STTR

Phase I Applicant (NHLBI, NIMHD, NICHD mechanisms)

SAM Registration

Active, Notarized Unique Entity ID (UEI) registered for government awards

Governance

Scientific Leadership & Advisory Boards

Combining clinical insight, computational rigor, and regulatory strategy to translate multi-omic research.

CEO & Leadership

Driving the strategic vision for AI/ML-enabled biomarker science.

🏛️

Dr. Shahid S. Siddiqui, Ph.D.

Founder and CEO, McGenome LLC
Chair and Professor of Foundational Biology, NCOM, Schaumburg, Illinois

Cross-Domain Leadership
Drug & Device DevelopmentRegulatory AffairsMolecular Biology

Molecular biologist and developmental geneticist with over 40 years of experience. Founded McGenome in 2004. Has developed siRNA-based reagents, obtained international patents, and contributed to drug clinical trials in oncology and cardiovascular diseases.

MD Physician Advisory Panel

Ensuring clinical relevance and translational validity for all biomarker hypotheses.

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Dr. Janie Myers, DO, DFACOS, FACS

Distinguished Fellowship Trained Surgeon

Rare Diseases & Systemic Conditions
Advanced Surgical TechniquesHealthcare Leadership

Leads Myers Surgical Associates honing skills in both advanced surgical techniques and business management. At the National Board of Osteopathic Medical Examiners, her role melds healthcare leadership with a steadfast commitment to regulatory compliance and utilization management.

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Prof. Dr. Timothy Andersson, Ph.D.

Clinical Research Expert

Dermatological & Systemic Autoimmune
Stem Cell ResearchClinical StudiesMedical Therapeutics

Has conducted phase three clinical studies demonstrating that plant stem cells in a proprietary vehicle were safe, tolerable, and significantly more beneficial in contributing superior clinical efficacy to treat various dermatological conditions and reverse aging.

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Douglas Yau, Ph.D, MBA, CMD

Executive Director Oncology Medical Affairs

Paediatric & Adult Oncology
Oncology Medical StrategyImmuno-oncologyAngel Investing

Inspirational Medical Affairs Leader with 15 years of experience in Biological Sciences and over 10 years specifically in Hematology and Oncology. Provides strategic leadership for national Oncology Solid Tumor Teams, supporting multiple successful Immuno-oncology drug launches.

Computational Science & Regulatory Team

Executing the multi-omic analytical pipelines and navigating FDA qualification pathways.

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Dr. Robert Holmgren, PhD

Director of Biological Programs

Rare Paediatric Cancer
Human GeneticsRare DiseaseHedgehog Signaling

Distinguished researcher with 40 years studying Hedgehog signal transduction, which plays a central role in animal development and human disease. His contributions include identification of new pathway components and development of compounds to block Hedgehog signaling in cancer.

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Dr. Syed Shahabuddin, Ph.D.

Drug Development Strategist

Sarcoidosis & Fibrotic Diseases
Small MoleculesGene TherapyCell Therapies

Drug development strategist with over 25 years of experience advancing therapeutics from discovery through late-stage clinical development. Founder of SS BioPharma Consulting, advising on cross-functional program execution.

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Dr. Jaseem Anwer, PhD

Scientific Director

Brain-Gut Axis
ToxicologyPharmacokineticsSafety Pharmacology

Leads analytical, bioanalytical, and safety pharmacology studies across various models. Over 20 years of experience in designing pre-clinical GLP and non-GLP studies.

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Dr. Haris Jamil, PhD

Pharmaceutical Development Leader

Biomarker Qualification
Analytical DevelopmentBiologics

Accomplished leader with three decades of experience guiding drug development across small molecules, peptides, and biologics. Contributed to major regulatory milestones including filing several INDs at Bristol-Myers Squibb.

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Dr. Shahab U. Khan, Ph.D.

Chief Scientific Officer

Grant Strategy & NIH Proposals
Clinical DevelopmentMedical Writing

Possesses deep proficiency in the full life cycle of clinical development. Experienced leader with a proven history of high-quality medical writing, including complex clinical protocols and successful grant proposals.

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Dr. Zeba K. Siddiqui, Ph.D.

Chief Financial Officer

Systemic Inflammation
Molecular ImmunologyStrategic Funding

Highly experienced molecular immunologist with research in pulmonary endothelial function and cell death pathway signaling. Has published in top-ranked peer-reviewed journals.

Global Network

International Scientific Affiliations

Advisory and educational leadership bridging oncology and precision medicine networks globally.

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Pharmatica — Scientific Council Member

Vanguard Science Education Platform · South Africa / United Kingdom

Founding Member · Launching 2026
OncologyPrecision MedicinePharmatica Forum

Pharmatica is an international science education platform connecting clinicians, researchers, and industry professionals across Africa, Europe, and beyond. Dr. Siddiqui contributes as a founding Scientific Council member, providing educational content on oncology advances, molecular diagnostics, and the application of AI/ML to drug development and disease monitoring. Webcasts are available through the Pharmatica forum.

Webcasts launching 2026 — link will be updated.

Research Space

Core Scientific Disciplines

Our research is cross-disciplinary, bringing computational and wet lab practices together.

Molecular Biology
Toxicology
Oncology
Regulatory Affairs
Biostatistics
Immunology
Archives

Selected Publications

Peer-reviewed evidence establishing the scientific basis of our platforms.

Human Genomics
2026

Alafghani et al. — KIF7 c.2992C>T, CEP104 c.489+1G>A, TMEM237 c.869+1G>A in Saudi consanguineous JSRD families. Index paper for KIF7-CilioPanel™.

Genomics
2016

Al-Allaf et al. — Recurrent LDLR frameshift in homozygous Saudi Arab children with familial hypercholesterolemia. Autosomal recessive founder allele genetics.

PNAS
2003

Yau et al. — Worm Gα12 activates the Rho guanine nucleotide exchange factor CGEF-1 to regulate cytoskeletal dynamics and cell migration.

J Cell Science
1999

Siddiqui — MEC-12 alpha-tubulin acetylation in C. elegans mechanosensory neurons. Axonemal scaffold biology.

J Mol Biol
1995

Tabish et al. — OSM-3 kinesin isoform selectively maintains sensory ciliary compartment identity in C. elegans. Foundational precedent for KIF7 ciliary tip biology.

DNA Research
2000

Khan et al. — KLP-11 / KAP-1 kinesin heterodimer in C. elegans sensory neurons. Ciliary transport mechanism.